FISH-RARA VARIANT TRANSLOCATION
Acute Promyelocytic Leukemia (APL) in its typical presentation expresses PML-RARA as seen in 95% of patients. These patients have good clinical outcome. However, 16 additional RARA rearrangements have been identified such as PLZF-RARA, GTF2I-RARA, NUMA-RARA, STAT5B-RARA etc. These cases of "Variant APL" have poor prognosis as compared to "Typical APL" as their reponse to typical therapy including ATRA & ATO is not good. This test is useful for verifying RARA status when morphology is suspicious for APL but t(15;17) FISH test is negative. The test helps in early identification of this group of patients so that they can switch from ATRA to standard chemotherapy.
Parameter(s) covered : 2
Report Frequency: Sample Daily by 4 pm; Report 4 Working days
Special Instruction: Duly filled Chromosome & FISH analysis Requisition Form (Form 17) is mandatory.
Price : ₹ 4300.00
Parameters
- RARA (17q21)
- RARA (17q21) VARIANT TRANSLOCATION ASSAY