LECT2
Amyloidosis, often a multiorgan disease is characterized by deposition of Congophilic fibrillary material with the affected organs composed of randomly oriented non- branching fibrils measuring about 7-11 nm in diameter. Among the commonly prevalent sub- types, AL amyloidosis is derived from immunoglobulin light chains and AA amyloid from serum amyloid A protein (AA). The less common variants include those derived from fibrinogen (AFib), transthyretin (ATTR), lysozyme (ALys), and apolipoproteins AI or AII (AApoAI, AApoAII).Amyloid deposits composed of leukocyte chemotactic factor 2 (LECT2) are described recently and in some series are found to be the third most common amyloid subtypes after AA and AL amyloid. Leukocyte cell-derived chemotaxin 2 (LECT2) was originally isolated and characterized from culture media of PHA-activated human T-cell leukemia cells as part of studies to identify chemotactic factors important in the pathophysiology of neoplasia. Although the original characterization of LECT2 proved to be of bovine origin from the fetal calf serum used in media, these studies led to the cloning and structural characterization of the human analog. The protein was independently characterized from fetal bovine cartilage and named chondromodulin II.The human LECT2 gene is localized to chromosome 5 (5q31.1–q32) and consists of four exons and three introns. The gene codes for 151 amino acids (MW 16 376 Da) including an 18 amino acid signal peptide. The secreted protein has 133 residues.
Parameter(s) covered : 1
Report Frequency: Sample Daily by 6 pm; Report Block: 5 days
Tissue Biopsy: 5 days
Tissue large complex : 7 days
Special Instruction: Provide a copy of the Histopathology report, Site of biopsy and Clinical history.
Price : ₹ 1800.00
Parameters
- LECT2