PURKINJE CELL (Yo) ANTIBODY SCREEN, WITH REFLEX TO TITER AND WESTERN BLOT, SERUM
Delta / Notch like epidermal growth factor related receptor (DNER) is a central nervous system specific ligand for the Notch receptors expressed by cerebellar purkinje neurons. These neurons are essential for the normal development of Purkinje cells & Bergmann glia. DNER is the target of PCA-Tr antibodies associated with Paraneoplastic cerebellar degeneration in patients with Hodgkin's lymphoma.
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