TPMT (THIOPURINE METHYL TRANSFERASE) GENOTYPING
Detection of TPMT genetic variants by genotyping is recommended prior to commencing the treatment of patients with Thiopurine drugs such as Azathioprine, 6-Mercaptopurine and 6-Thioguanine for Acute Lymphoblastic Leukemia & autoimmune disorders like Crohn's disease & Rheumatoid arthritis.TPMT is an enzyme which converts these drugs in the body to an active form. Any genetic defect in this enzyme predisposes patients to a heightened risk of drug-induced bone marrow toxicity due to accumulation of unmetabolised drug. Approximately 0.3% of individuals lack TPMT activity while 11% show reduced activity (variants TPMT*2, 3A & 3C). 89% of people have normal activity (variant TPMT*1).
Parameter(s) covered : 5
Report Frequency: Sample Mon through Sat by 10 am; Report Next day
Special Instruction: Physician prescription is mandatory.
Price : ₹ 5600.00
Parameters
- TPMT*1 wild type
- TPMT*2 G238C
- TPMT*3A G460A and A719G
- TPMT*3B G460A
- TPMT*3C A719G